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| Region | Game | Venue | Time (ET) | TV | Announcers |
|---|---|---|---|---|---|
| MidWest | Mercer Bears (14) vs. Duke Blue Devils(3) | PNC Arena (Raleigh, NC) | 12:15p | CBS | Kevin Harlan/Len Elmore/Reggie Miller/Rachel Nichols |
| West | Nebraska Cornhuskers (11) vs. Baylor Bears (6) | AT&T Center (San Antonio, TX) | 12:40p | truTV | Marv Albert/Steve Kerr/Craigh Sager |
| South | Stanford Cardinal (10) vs. New Mexico Lobos (7) | Scottrade Center (St. Louis, MO) | 1:40p | TBS | Jim Nantz/Greg Anthony/Tracy Wolfson |
| West | Weber State Wildcats (16) vs. Arizona Wildcats (1) | Viejas Arena at Aztec Bowl (San Diego, CA) | 2:10p | TNT | Andrew Catalon/Mike Gminski/Otis Livingston |
| MidWest | Tennessee Volunteers (11) vs. Massachusetts Minutemen (6) | PNC Arena (Raleigh, NC) | 2:45p | CBS | Kevin Harlan/Len Elmore/Reggie Miller/Rachel Nichols |
| West | Louisiana-Lafayette Ragin' Cajuns (14) vs. Creighton Bluejays (3) | AT&T Center (San Antonio, TX) | 3:10p | truTV | Marv Albert/Steve Kerr/Craigh Sager |
| South | Eastern Kentucky Colonels (15) vs. Kansas Jayhawks (2) | Scottrade Center (St. Louis, MO) | 4:10p | TBS | Jim Nantz/Greg Anthony/Tracy Wolfson |
| West | Oklahoma State Cowboys (9) vs. Gonzaga Bulldogs (8) | Viejas Arena at Aztec Bowl (San Diego, CA) | 4:40p | TNT | Andrew Catalon/Mike Gminski/Otis Livingston |
| East | George Washington Colonials (9) vs. Memphis Tigers (8) | PNC Arena (Raleigh, NC) | 6:55p | TBS | Kevin Harlan/Len Elmore/Reggie Miller/Rachel Nichols |
| MidWest | Cal Poly Mustangs (16) vs. Wichita State Shockers (1) | Scottrade Center (St. Louis, MO) | 7:10p | CBS | Jim Nantz/Greg Anthony/Tracy Wolfson |
| East | Providence Friars (11) vs. North Carolina Tar Heels (6) | AT&T Center (San Antonio, TX) | 7:20p | TNT | Marv Albert/Steve Kerr/Craigh Sager |
| South | Stephen F. Austin Lumberjacks (12) vs. Virginia Commonwealth Rams (5) | Viejas Arena at Aztec Bowl (San Diego, CA) | 7:27p | truTV | Andrew Catalon/Mike Gminski/Otis Livingston |
| East | Coastal Carolina Chanticleers (16) vs. Virginia Cavaliers (1) | PNC Arena (Raleigh, NC) | 9:25p | TBS | Kevin Harlan/Len Elmore/Reggie Miller/Rachel Nichols |
| MidWest | Kansas State Wildcats (9) vs. Kentucky Wildcats (8) | Scottrade Center (St. Louis, MO) | 9:40p | CBS | Jim Nantz/Greg Anthony/Tracy Wolfson |
| East | NC Central Eagles (14) vs. Iowa State Cyclones (3) | AT&T Center (San Antonio, TX) | 9:50p | TNT | Marv Albert/Steve Kerr/Craigh Sager |
| South | Tulsa Golden Hurricane (13) vs. UCLA Bruins (4) | Viejas Arena at Aztec Bowl (San Diego, CA) | 9:57p | truTV | Andrew Catalon/Mike Gminski/Otis Livingston |